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Global Healthspan Study
Human healthspan is a sociological issue and is associated with many factors, including not only physical and physiological factors but also lifestyle, social, educational and psychological factors. Thus, research into human healthspan requires many kinds of examinations and specialists in various areas. In addition, human healthspan research requires long-term study in which the same subjects are measured repeatedly to observe age-related changes.
The Global Healthspan conducts a longitudinal study of human aging associated with epigenetic changes, resulting in alterations of gene expression and disturbances in broad genome architecture and the epigenomic landscape. The potential reversibility of these epigenetic changes offers exciting opportunities to alter the trajectory of age-related diseases.
Very few longitudinal studies of aging have collected biomarker, genetic or epigenetic data to reveal the process of aging, and to study how biological processes interact with physical and psychosocial environments to produce deleterious health outcomes. While genetic variation undoubtedly contributes to general aging and certain age-related diseases, there are many cases of very closely related individuals with the same genetic markers showing substantial variation in the age of onset of, or severity of, disease. There is also evidence that the incidence of disease varies according to life circumstances, or lifestyle.
Epigenetics provides an attractive concept for such mediators, as the epigenome has dynamic features that can be altered by both the physical and lifestyle factors, in addition to being strongly affected by nutritional factors. Therefore, the epigenome in theory could change during the life course as part of the normal developmental program and in response to many life factors.
The objective of the Global Healthspan Study is to understand the mechanisms affecting human healthspan and empower people of all ages, backgrounds, and lifestyles to live healthier, happier, longer lives. The project intends to follow approximately one million men, women and children when recruited from all over the world, for at least 10 years. With the data we collect, we expect to be able to identify the specific genetic and epigenetic predictors of health & wellness, aging, and lifestyle-related diseases.
Questionnaires, surveys, DNA sample collection
Self tracking, lifestyle coaching, wellness program implementation
Data gathering, preventive protocol refinement
Preventive protocol implementation, disease specific preventive research
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